Lexaria Oral Delivery Technology Outperforms GLP-1 Drug, Rybelsus®

Lexaria Bioscience (Nasdaq: LEXX) has reported positive final results from a pilot study evaluating its DehydraTECHTM technology for the oral delivery of the GLP-1 drug semaglutide, marketed as Rybelsus®.

The study demonstrated that DehydraTECH-powered semaglutide achieved sustained, higher levels of semaglutide in blood, better blood glucose control, faster achievement of peak drug delivery, and reduced side effects.

Lexaria is now preparing for other human and animal studies to continue the evaluation of DehydraTECH’s effectiveness with GLP-1 drugs.

Highlights

Lexaria’s study was conducted by a prominent university research center, and compared a single 7mg semaglutide dose of a Rybelsus® tablet to a matching dose from Rybelsus that had been compound formulated in capsule form using DehydraTECH processing technology enhancements.

Seven healthy subjects were dosed with each test article following a cross over study design across two study visits.

Peak levels of semaglutide in blood were 43% higher in the DehydraTECH GLP-1 than in the Rybelsus® Control, and 24 hours after the ingestion of the single dose, DehydraTECH GLP-1 blood semaglutide levels were approximately 44% higher than Control levels.

DehydraTECH GLP-1 reduced blood glucose to lower levels and was much more effective at maintaining consistently reduced blood glucose levels.

The DehydraTECH GLP-1 processed semaglutide was generally better tolerated than the Rybelsus® tablets themselves, which causes instances of moderate nausea and moderate diarrhea.

About Lexaria Bioscience Corp.

Lexaria Bioscience Corp.’s patented drug delivery technology, DehydraTECH™, improves the way active pharmaceutical ingredients (APIs) enter the bloodstream through oral delivery. Since 2016, DehydraTECH has repeatedly demonstrated the ability to increase bio-absorption with cannabinoids, antiviral drugs, PDE5 inhibitors and more. DehydraTECH has also evidenced an ability to deliver some drugs more effectively across the blood brain barrier. Lexaria operates a licensed in-house research laboratory and holds a robust intellectual property portfolio with 38 patents granted and many patents pending worldwide. For more information, please visit www.lexariabioscience.com.

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About the Author

Lexaria Oral Delivery Technology Outperforms GLP-1 Drug, Rybelsus®

Catie Corcoran

Biotech Editor