PRISM Stock IndexesCurrent Value% Change (Daily)% Change (Inception)Most ActiveTop % GainersTop % Losers
AI Datacenter and Infrastructure$467.300.8%367.3%APLD 15,563 TSSI  7.676%SLNH -2.208%
AdTech and Media$166.10-1.4%66.1%FUBO 9,945 IHRT  6.061%BBLR -11.765%
Biotech$133.60-1.8%33.6%TSHA 4,052 CAPR  14.23%PALI -15.049%
Cannabis$79.800.9%-20.2%TLRY 25,758 AYRWF  12.871%HITI -5.46%
Consumer Products$104.600.1%4.6%PTON 17,209 BBW  22.6%OTLY -5.421%
EV$72.301.7%-27.7%LCID 51,984 EZFL  26%LTHM -8.532%
Global Health$261.20-2.7%161.2%ESPR 4,252 ALGS  8.495%NKGN -10.523%
Healthcare$81.80-0.5%-18.2%BMRA 840 CCLD  12.857%OWLT -8.163%
NextGen Tech & AI$215.000.2%115.0%SOUN 29,555 SOUN  31.33%FTFT -10.854%
New Energy$87.30-0.6%-12.7%DNN 20,843 UROY  12.393%NOVA -5.733%
MedDevices$120.20-2.1%20.2%HUMA 3,050 MYO  11.215%PAVM -12.829%
Mental Health$64.50-3.6%-35.5%BNOX 9,628 RVPH  14.4%SEEL -31.494%
Oil & Gas$86.70-0.7%-13.3%KOS 7,778 ALVOF  3.175%ICD -9.877%
Pharmaceuticals$166.80-2.1%66.8%TNXP 37,537 CADL  10.61%BDRX -19.7%
Psychedelics$251.60-4.5%151.6%MIRA 1,485 ENVB  3.835%RLMD -28.571%
Weight Loss$223.50-4.1%123.5%HIMS 15,491 SRRK  5.255%RSLS -11.786%
Women’s Health$144.600.4%44.6%ITRM 2,627 ITRM  18.828%PDSB -6.977%

Prism View

The Great Energy Equation: How Data Centers, EVs, and AI Are Transforming the Grid and Spurring Innovation

As the world accelerates into a digitally driven era, the escalating energy demands of data centers, electric vehicles (EVs), and artificial intelligence (AI) are exerting unprecedented pressure on global power grids. This surge presents both formidable challenges and compelling opportunities…

Digital Dinero: As Bitcoin Surpasses $100K, El Salvador Has Unrealized Profits Over $300M

After President-elect Donald Trump nominated the crypto crusader Paul Atkins as the next SEC Chair, Bitcoin rallied to its all-time high, surpassing $100K as other crypto stocks mimicked the upward momentum.  Shares of Coinbase (COIN) climbed on the open and…

Stocks making the biggest moves premarket: American Eagle Outfitters, Five Below, MicroStrategy & more

Take a glance at the corporations that have been in the spotlight in pre-market trading. American Eagle Outfitters The clothing retailer's shares plunged almost 14% due to a lackluster holiday forecast. American Eagle Outfitters expects a mere 1% rise in…

Trump Nominates SEC Chair: Who is Paul Atkins and What to Expect

Today it was announced that President-elect Donald Trump has nominated former SEC member, Paul Atkins to…

Hut 8 Launches $500M ATM Program and Stock Buyback to Drive Bitcoin Mining Expansion

Hut 8 Corp. (Nasdaq | TSX: HUT), a leader in energy infrastructure and Bitcoin mining, has…

The “Check Engine” Light Is On: General Motors Reports Over $5Bn Charge Related to China

General Motors (NYSE: GM) announced it will record two non-cash charges totaling over $5Bn billion related…

Small-Cap Oil and Gas Firms Await a Boom Under Trump’s Deregulatory Push

The oil and gas sectors are poised for significant transformation as President-elect Donald Trump prepares to…

Stocks making the biggest moves premarket: Salesforce, Foot Locker, Pure Storage, PSQ Holdings & more

Business Highlights Before Market Open: Salesforce — An impressive 12% surge in shares has been noticed…

Texas: Pioneering the Future of Green Hydrogen Production

Texas stands at the forefront of a potential energy revolution, positioning itself as a key player…

Feature Story

PRISM Holiday Gift Guide: Top Trendy Tech Gadgets for Every Enthusiast

The holiday season has kicked off and is now in full swing as consumers pulled out their pocketbooks to make their Black Friday and Cyber Monday purchases. It comes as no surprise that Black Friday had more success from online sales than in-store. According to Mastercard SpendingPulse, this Black Friday online sales surged 14.6% year-over-year (y/y), significantly outpacing in-store sales, which rose a modest 0.7%. Cyber Mondayreinforced online retail strength with Adobe Analytics reporting Americans spent $13.3Bn, up 7.3% from last year. Besides the convenience, the online sales uptick is attributed to steeper discounts and a persistent push from retailers that included mass emailing, push notifications, chat bot assistance and ‘buy now, pay later’ services which hit $991M in spending. (more…)

Q&A Corner

Peter Moriarty

Klotho Neurosciences Reviews the Secreted Klotho Gene (s-KL) and Its Potential in Treating Aging and Neurodegenerative Diseases Such as Alzheimer’ Disease

In light of Alzheimer’s Awareness Month, Klotho Neurosciences COO, Peter Moriarty, discusses how the Klotho gene in its secreted form may hold the key to treating multiple neurodegenerative diseases.

November is Alzheimer’s Awareness Month which focuses on increasing understanding of Alzheimer’s and the impact it has on the 6.2 million Americans suffering from the disease. Alzheimer’s disease is a progressive, age-related neurodegenerative disease affecting memory, cognition, and behavior.  It is the most common cause of dementia, accounting for 60-80% of cases. Historically, Alzheimer’s treatments focused on managing symptoms without addressing the disease’s underlying biology. However, a new generation of therapies is targeting key mechanisms, such as protein accumulation, inflammation, and disrupted neuronal communication.

Recent groundbreaking research and emerging therapies have been aimed at enhancing human health and longevity. In particular, researchers have examined the secreted form of the Klotho gene, or s-KL and its powerful role in aging, which may hold the key to healthier aging and the treatment of devastating diseases like Alzheimer’s, ALS, and Parkinson’s.

PRISM MarketView spoke with Klotho Neurosciences (Nasdaq: KLTO) Chief Operating Officer, Peter Moriarty, who shared insights on what scientists know about the secreted form of Klotho, the exciting research surrounding it, and what the future might hold for this potential anti-aging therapy.

Traders Lens

ChargePoint Holdings, Inc.

$CHPT is leading the Prism MarketView EV index today after the company narrowed its net loss and posted higher-than-expected revenue in its fiscal third quarter

Capricor Therapeutics, Inc.

$CAPR is the biggest laggard of the Prism MarketView Biotech index and is trading at the lower end of its range over the past couple of months which looks to be an important support level in the near term.

Esperion Therapeutics, Inc.

$ESPR is leading the Prism MarketView Public Health Index after the company said it has filed new submissions to Health Canada for Nexletol and Nexlizet, non-statin medications that reduce low-density lipoprotein cholesterol and cardiovascular risk.

Bio View

Protara Stock Surges 116% on Breakthrough Bladder Cancer Trial Results

Protara Therapeutics, Inc. (Nasdaq: TARA) announced promising results from its Phase 2 ADVANCED-2 trial, sending its stock soaring 116%. The trial evaluated TARA-002, the company’s investigational cell-based therapy for Non-Muscle Invasive Bladder Cancer (NMIBC), and demonstrated significant efficacy and safety…

Stoke Therapeutics Wins FDA Breakthrough Therapy Designation for Dravet Syndrome Treatment

Stoke Therapeutics (Nasdaq: STOK) announced that its investigational therapy, zorevunersen, has received Breakthrough Therapy Designation from the U.S. Food and Drug Administration (FDA) for the treatment of Dravet syndrome with a confirmed mutation in the SCN1A gene. This designation recognizes…

Applied Therapeutics Charts Path Forward After FDA Setback, Eyes European Approval and Pipeline Expansion

Applied Therapeutics (NASDAQ: APLT) received a warning letter from the FDA concerning its study of govorestat, a drug intended to treat the rare genetic disease galactosemia. This follows last week’s FDA rejection of the drug’s marketing application, citing deficiencies. The…

Janux Therapeutics Surges Over 60% on Promising Prostate Cancer Drug Results

Janux Therapeutics (NASDAQ: JANX) reported groundbreaking results from its trial of a new drug for heavily…

Delcath Systems Green-Lit by FDA for Phase 2 Trial in Liver-Dominant Metastatic Colorectal Cancer

Delcath Systems, Inc. (NASDAQ: DCTH), a company specializing in interventional oncology, announced that the U.S. Food…

Silo Pharma Enters Joint Development Agreement for Ketamine Implant Device Targeting Pain Management

Silo Pharma, Inc. (Nasdaq: SILO), a developmental biopharmaceutical company focused on innovative therapeutics and drug delivery…

Acadia Pharmaceuticals Licenses SAN711 from Saniona for Essential Tremor Treatment

Acadia Pharmaceuticals Inc. (Nasdaq: ACAD) has entered into an exclusive worldwide license agreement with Saniona (OMX:…
PRISM Indexes

European luxury stocks gain as Goldman sees ‘modest’ growth in 2025

Despite the tempered growth outlook, this reassessment has created opportunities for selective stock investments within the industry. The note underscores the importance of long-term structural drivers,… [Read More]