Lipella Pharmaceuticals (LIPO) Announces Early Tolerability Results in Phase 2a Trial for Oral Lichen Planus

Today the clinical stage biopharmaceutical company Lipella Pharmaceuticals (LIPO) reported encouraging tolerability results in its Phase 2a trial for its Oral Lichen Planus (OLP) treatment, LP-310.  Three participants have completed the four-week treatment with LP-310, an oral rinse and have reported the treatment was well tolerated with no unpleasant taste.

LP-310 is derived from Lipella’s lead candidate, LP-10 which had been originally developed to target hemorrhagic cystitis. LP-310 is a proprietary liposomal-tacrolimus formulation that targets underlying causes of OLP in an effort to provide a more effective alternative to the current treatment options. Currently, there are no FDA-approved pharmacotherapies for Oral Lichen Planus, and LP-310 is the only topical treatment in development for OLP.

Dr. Michael Chancellor, Chief Medical Officer of Lipella Pharmaceuticals, commented, “Oral Lichen Planus is a highly disruptive condition that significantly impacts patients’ daily lives. Given the severity of symptoms, tolerability is critical. Symptomatic side effects from current treatments often lead to frequent dose interruptions or delays, which can further complicate disease management. The fact that LP-310 has been well tolerated so far, without unpleasant taste, is very encouraging. We look forward to gathering more data on the safety side as we continue this pivotal trial.”

About Lipella Pharmaceuticals 
Lipella is a clinical-stage biotechnology company focused on developing new drugs by reformulating the active agents in existing generic drugs and optimizing these reformulations for new applications. Additionally, Lipella maintains a therapeutic focus on diseases with significant, unaddressed morbidity and mortality where no approved drug therapy currently exists. Lipella completed its initial public offering in December 2022. For more information, please visit www.lipella.com or LinkedIn .

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Lipella Pharmaceuticals (LIPO) Announces Early Tolerability Results in Phase 2a Trial for Oral Lichen Planus

Ashlee Vogenthaler

Markets Editor