Silence Therapeutics

Our 20-plus years of RNAi experience together with our validated mRNAi GOLD™ platform make us a
partner of choice for pharmaceutical companies looking to access the benefits of the siRNA and add
this revolutionary modality to their discovery pipeline. As pioneers in the design and development of
siRNAs (short interfering RNAs), Silence Therapeutics is advancing a new generation of medicines to
potentially address the needs of patients who have limited or inadequate treatment options.
Our mission is to use our technology to create a new generation of therapeutics which can improve
outcomes for patients and, in the process, build shareholder value.
We are developing a deep pipeline of innovative siRNAs based on our mRNAi GOLD™ platform for
diseases with a genetic basis. The depth and versatility of our liver-targeting technology gives us the
opportunity to address a wide range of conditions in virtually any therapeutic area.