Quoin Pharmaceuticals Announces Positive Data in Rare Disease Clinical Trial
October 24, 2023 at 2:58 pm - by Catie Corcoran
Specialty pharmaceutical company, Quoin Pharmaceuticals (Nasdaq: QNRX) has announced additional positive clinical data from its ongoing open-label study evaluating the safety and efficacy of QRX003 as a potential treatment for Netherton Syndrome (NS).
Quoin CEO, Dr. Michael Myers, said, “While acknowledging that this is still early stage data, we are very pleased to announce today additional positive results from our ongoing open-label study in Netherton Syndrome. The results for pruritus are particularly encouraging, as this often causes significant distress for Netherton patients. In addition, there are well defined efficacy signals across the other evaluated endpoints including skin appearance and the subjects’ own impression of how QRX003 performed throughout the study, indicating that QRX003 may have the potential to become an effective treatment for Netherton Syndrome.”
Highlights
This study is an open-label, single-arm trial evaluating 10 NS patients dosed with QRX003 over a 12-week period. All subjects in the study are continuing to receive off-label systemic therapy for the duration of the trial.
Of the available data from six evaluable subjects, five demonstrated a well-defined positive improvement in pruritus, or itch, with those five subjects reporting absent or negligible pruritus on completion of dosing with QRX003 based on the endpoint scoring system.
All six patients experienced an improvement in skin appearance, and all of the 6 subjects indicated a positive impression of QRX003 across a number of key metrics.
Quoin stated that it is moving into an optimization phase for this study as well as the company’s ongoing double blinded clinical trial.
The active ingredient in QRX003 is a broad-spectrum serine protease inhibitor, whose mechanism of action is intended to down-regulate the hyperactivity of skin kallikreins, leading to a more normalized rate of skin shedding.
Netherton Syndrome is a devastating and sometimes fatal rare disease.
About Quoin Pharmaceuticals
Quoin Pharmaceuticals Ltd. is a clinical stage specialty pharmaceutical company focused on developing and commercializing therapeutic products that treat rare and orphan diseases. We are committed to addressing unmet medical needs for patients, their families, communities and care teams. Quoin’s innovative pipeline comprises four products in development that collectively have the potential to target a broad number of rare and orphan indications, including Netherton Syndrome, Peeling Skin Syndrome, Palmoplantar Keratoderma, Scleroderma, Epidermolysis Bullosa and others. For more information, visit: www.quoinpharma.com or LinkedIn for updates.
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