Alkermes Takes on Narcolepsy at World Sleep Congress
Alkermes plc (Nasdaq: ALKS) is set to present new data related to ALKS 2680, the company’s novel, investigational orexin 2 receptor (OX2R) agonist in development for the treatment of narcolepsy, at World Sleep Congress, taking place Oct. 20-25, 2023, in Rio de Janeiro.
Craig Hopkinson, M.D., Chief Medical Officer and Executive Vice President of Research & Development at Alkermes, said, “As a leader in the field of neuroscience, Alkermes is excited to leverage its expertise in pursuit of the development of a potential new treatment option for narcolepsy. We look forward to presenting data at the World Sleep Congress, including our first clinical data for ALKS 2680 in patients with narcolepsy.”
Highlights
Alkermes will present initial data from its ongoing phase 1 study evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of ALKS 2680 in healthy volunteers and patients with narcolepsy or idiopathic hypersomnia.
This presentation will include initial clinical proof-of-concept data from the first cohort of four patients with narcolepsy type 1.
In a separate presentation, the company will share results from a preclinical study evaluating the effect of ALKS 2680 (RDC-264177) on wakefulness and cataplexy in a mouse model of narcolepsy type 1.
Alkermes says the design and development of ALKS 2680 is grounded in its medicinal chemistry capabilities coupled with a strong biological rationale for the use of orexin agonists in the treatment of narcolepsy.
About Alkermes
Alkermes plc is a fully-integrated, global biopharmaceutical company developing innovative medicines in the fields of neuroscience and oncology. The company has a portfolio of proprietary commercial products focused on alcohol dependence, opioid dependence, schizophrenia and bipolar I disorder, and a pipeline of product candidates in development for neurological disorders and cancer. Headquartered in Dublin, Ireland, Alkermes has a research and development (R&D) center in Waltham, Massachusetts; a research and manufacturing facility in Athlone, Ireland; and a manufacturing facility in Wilmington, Ohio. For more information, please visit Alkermes’ website at www.alkermes.com.
